Inflammation and vascular remodeling in COVID-19 heartsMulticenter Study Published on 2023-05-012023-06-23 Journal: Angiogenesis [Category] SARS, 신종인플루엔자, [키워드] Acute heart failure Angiogenesis CD11b Coronavirus disease 2019 COVID-19 heart intussusception Intussusceptive angiogenesis macrophages TIE2. [DOI] 10.1007/s10456-022-09860-7 PMC 바로가기 [Article Type] Multicenter Study
COVID-19 and Pulmonary Angiogenesis: The Possible Role of Hypoxia and Hyperinflammation in the Overexpression of Proteins Involved in Alveolar Vascular DysfunctionArticle Published on 2023-03-082023-06-23 Journal: Viruses [Category] 신종인플루엔자, [키워드] Angiogenesis Endothelial dysfunction immunohistochemistry microthrombi. SARS-CoV-2 [DOI] 10.3390/v15030706 PMC 바로가기
Skin capillary alterations in patients with acute SarsCoV2 infectionArticle Published on 2022-12-012022-11-16 Journal: Journal of hypertension [Category] COVID19(2023년), SARS, 치료기술, [키워드] A significant reduction acute infection acute phase addition alteration Angiogenesis Autopsy blood chemistry C-reactive protein capillary complications correlation COVID-19 demonstrated discharge endothelial damage Endothelial dysfunction Endothelitis evaluated events Evidence explain hospital impairment incidence increase in Infection Inflammation Inflammatory marker inverse correlation Ischemia lymphocyte material oedema organ parameter Patient patients procoagulant promote repeated resulting skin the disease thrombosis tissue vascular effect vasoconstriction viral infection with COVID-19 [DOI] 10.1097/HJH.0000000000003271 PMC 바로가기
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaquesSARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경Article Published on 2022-12-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis. [DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article
Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasiaArticle Published on 2022-11-072022-11-16 Journal: Orphanet Journal of Rare Diseases [Category] 유전자 메커니즘, [키워드] analysis Angiogenesis assigned Biomarkers bleeding Blood center double-blind doxycycline Effectiveness ENG Epistaxis Frequency heart failure help hemorrhage Hemorrhagic Hereditary Hereditary hemorrhagic telangiectasia Hereditary hemorrhagic telangiectasia. HHT IL-6 Inflammatory intravenous limitations Liver disease malformation marker mechanism Michael morbidity no significant difference not significantly different observation pathway Patient Placebo placebo-controlled provided Quality of life Randomized controlled trial Randomly RBC recruited Registered Registration secondary significantly higher stroke telangiectasia therapy Toronto Treatment treatment period Trial VEGF [DOI] 10.1186/s13023-022-02539-8 PMC 바로가기
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanismArticle Published on 2022-10-102022-11-15 Journal: Molecular Medicine [Category] 바이오마커, [키워드] Accuracy acute COVID-19 Angiogenesis AUC Biomarker Biomarkers Blood case-control study characterized Cohort COVID-19 Diagnosis diagnostics disease elevated Endoglin female Follow-up Health healthy control ICAM-1 immunoassay Inpatient Intervention investigated lack long-COVID machine machine learning marker median multiplex outpatients pathophysiological mechanism Patient patients Post-infection Sensitivity and specificity Sex significantly Specific subject Symptom targeted therapy therapeutic efficacy unique Vascular Vascular transformation. vasculature VCAM-1 VLA-4 [DOI] 10.1186/s10020-022-00548-8 PMC 바로가기
Serum biomarkers associated with SARS-CoV-2 severityArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] acute phase Angiogenesis Asymptomatic biological marker Biomarker cardiovascular diseases chemokine Clinical course controls correlated cytokine D-dimer disease disease severity elevated evaluated Factor group groups Growth factors help Hospitalized identify immune response individual infected with SARS-CoV-2 Infection Mild negative control Patient patients with SARS-CoV-2 prognostic Prognostic markers RT-PCR SARS-CoV-2 SARS-COV-2 infection sera Severe case severity [DOI] 10.1038/s41598-022-20062-5 PMC 바로가기
Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patientsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA microRNA. Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19 [DOI] 10.3389/fimmu.2022.968991 PMC 바로가기
Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In VitroME/CFS가 있거나 없는 포스트 코로나19 증후군 환자의 혈청은 체외 내피 세포 기능에 차등적으로 영향을 미칩니다Article Published on 2022-08-022022-09-11 Journal: Cells [Category] 바이오마커, [키워드] Activation analysed Angiogenesis autoantibodies autoantibody binding Cell chronic fatigue syndrome compensatory mechanism COVID-19 Cytokines demonstrated develop Diagnostic Criteria dysregulated Effect Encephalomyelitis endothelial endothelial cells Endothelial dysfunction fatigue fatigue syndrome flow cytometry function functional groups healthy control healthy controls hypothesise in vitro investigated involved marker mechanism molecules Myalgic encephalomyelitis/chronic fatigue syndrome nitric oxide Patient patient cohort patient group patient groups patients post-COVID syndrome. profile promoted proportion reduced screened secretion sera serum serum cytokines significantly significantly increased small molecule Small molecules syndrome vascular remodelling was measured while [DOI] 10.3390/cells11152376 PMC 바로가기 [Article Type] Article
Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy임신 중 자간전증 및 COVID-19의 내피 및 혈관 신생 프로파일의 차이 및 유사성Article Published on 2022-08-012022-08-31 Journal: American journal of obstetrics and gynecology [Category] MERS, 바이오마커, 진단, [키워드] absence activate addition Adhesion Molecule alteration Analysis Angiogenesis angiogenic factors angiopoietin Antigen Biomarker Biomarkers C5b9 Cell cell membrane cell membranes Cell signaling change changes in circulating Coagulation Coagulopathy component Concentration Control controls COVID-19 COVID-19 infection COVID-19 patients Culture demonstrated difference differential diagnosis differentiation disease disorder endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction evaluated exhibited expected explained expression Extracellular Extracellular matrix group growth growth factor healthy heparan sulfate hypertensive hypertensive disorders of pregnancy Immunoblots immunofluorescence in some in vitro increase in Infection Inflammation inflammatory signaling innate immune response intercellular intercellular adhesion molecule less lysate lysates Mild mitogen-activated protein kinase Necrosis neutrophil Neutrophil extracellular trap Neutrophil extracellular traps normotensive overexpression Pathways Patient Phosphorylation placental placental growth factor preeclampsia Pregnancy pregnant women Principal component principal component analysis profile profiles Protein protein kinase receptor reduced reduction reduction in SARS-CoV-2 sera severe COVID-19 severe COVID-19 patient signaling pathway significant increase significantly increased Signs and symptoms similarity soluble fms-like tyrosine kinase-1 soluble tumor necrosis factor-α receptor I Spectrum statistical analysis statistically Study design sulfate Symptom Tumor tumor necrosis tumor necrosis factor-α tyrosine variable variance vascular cell adhesion von Willebrand disease von Willebrand factor von Willebrand factor. with COVID-19 women [DOI] 10.1016/j.ajog.2022.03.048 PMC 바로가기 [Article Type] Article